Description of the technology
OralPAS Pro® platform, is a solid-SMEDDS dosage form composed of peptide drug, solvent, co-solvent, and surfactant adsorbed onto granules by inert excipients. Once platform is exposed to the fluids of gastrointestinal (GI) tract, peptide drug, surfactant and co-solvent are released from granules, and then rapidly spontaneously emulsify to form very fine globules (size, 100-200 nm) which entrap peptide drug in the nanoemulsion droplet core to against enzyme degradation and to enhance permeability, resulting in improvement of peptide drugs absorption through oral administration.
Merits of OralPAS Pro®
1. Enhancing the oral bioavailability of peptide drugs
2. Providing longer period of storage for peptide drugs
3. A simple, scalable and replicable manufacturing process
2. Providing longer period of storage for peptide drugs
3. A simple, scalable and replicable manufacturing process
Application of peptides
1. Insulin
2. Glucagon-like peptide-1 analogues
3. Parathyroid hormone (PTH)
2. Glucagon-like peptide-1 analogues
3. Parathyroid hormone (PTH)
資料建置中!!
